HOXA5 INHIBITS THE PROLIFERATION OF EXTRAHEPATIC CHOLANGIOCARCINOMA CELLS BY ENHANCING MXD1 EXPRESSION AND ACTIVATING THE P53 PATHWAY

HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway

Abstract Homeobox A5 (HOXA5) is a transcription factor in mammalian and can regulate cell differentiation, proliferation, and apoptosis as well as tumorigenesis.However, little Inner Door Moulding is known on whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma.The methylation levels of HOXA5 were evaluated by methylatio

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AMC-Loaded Low-Profile Broadband Printed 2×2 Array With Gain and Isolation Enhancement Using Equivalent Circuit Model for Wireless Systems

A $2 imes 2$ array of printed antenna loaded by planar Giuseppe Peano artificial magnetic conductor (AMC) is presented for vehicular wireless systems.The four-element of the proposed array by utilizing diverse polarized directions of the printed dipoles with a $5 imes 5$ AMC reflector achieves a wideband antenna with enhanced properties.It shows th

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Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells

Human rhinoviruses (HRVs) are associated with acute exacerbations in patients with chronic obstructive pulmonary disease (COPD) and asthma, which are accompanied by mucus hypersecretion.Whereas, various studies have shown that HRVs increase epithelial mucin production and thus may directly contribute to mucus hypersecretion.The effects of drugs use

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Exploring optimal joint operating rules for large-scale inter-basin water transfer projects with multiple water sources, diversion routes, and water demand areas

Study region: The Jiangsu Province section of the South-to-North Water Diversion Project (JS-SNWDP) is an essential section of the SNWDP, which includes multiple water sources, diversion routes, and water demand areas.Study focus: Exploring effective operating rules for the JS-SNWDP is critical to improving its long-term operational performance.How

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